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2022 Mayfield Football Schedule
| DATE | OPPONENT | SITE | GAME TIME | RESULTS | VIDEO |
| Aug 19, 2022 | Graves County | AWAY | 7:00 | W 36-0 | Video |
| Aug 26, 2022 | Hopkinsville | HOME | 7:30 | W 36-0 | Video |
| Sep 2, 2022 | Paducah Tilghman | HOME | 7:00 | W 16-14 | Video |
| Sep 9, 2022 | McCracken County | AWAY | 7:00 | W 49-26 | Video |
| Sep 16, 2022 | Calloway County | AWAY | 7:00 | W 62-7 | Video |
| Sep 23, 2022 | Fort Campbell | HOME | 7:00 | W 50-7 | Video |
| Sep 30, 2022 | Caldwell County | HOME | 7:00 | W 49-7 | Video |
| Oct 14, 2022 | Ballard County | AWAY | 7:00 | W 50-0 | Video |
| Oct 21, 2022 | Murray | AWAY | 7:00 | W 42-10 | Video |
| Oct 28, 2022 | Madisonville North | HOME | 7:00 | W 50-10 | Video |
| Nov 4, 2022 | Todd County Central | HOME | 7:00 | W 43-22 | Video |
| Nov 11, 2022 | Murray | HOME | 7:00 | W 49-14 | Video |
| Nov 18, 2022 | Metcalfe County | HOME | 7:00 | W 28-0 | Video |
| Nov 25, 2022 | Lexington Christian Academy | HOME | 7:00 | W 38-28 | Video |
| Dec 2, 2022 | Beechwood | AWAY (Kroger Field) | 3:00 CST | L 13-14 | |