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2010 Mayfield Football Schedule
| DATE | OPPONENT | SITE | GAME TIME | RESULTS | VIDEO |
| Aug 20, 2010 | Marshall County | HOME | 7:30 | (W) 50-16 | Watch Video |
| Aug 28, 2010 | Trigg County | HOME-Alliance Bowl | TBA | (W) 45-7 | Watch Video |
| Sep 3, 2010 | Paducah Tilghman | HOME | 7:30 | (W) 23-20 OT | Watch Video |
| Sep 10, 2010 | Calloway County | AWAY | 7:30 | (W) 48-0 | Watch Video |
| Sep 17, 2010 | Graves County | AWAY | 7:30 | (W) 45-18 | Watch Video |
| Sep 24, 2010 | Fulton County | HOME | 7:30 | (W) 75-6 | Watch Video |
| Oct 1, 2010 | Fulton City | AWAY | 7:30 | (W) 51-6 | Watch Video |
| Oct 8, 2010 | Ballard Memorial | AWAY | 7:30 | (W) 52-0 | Watch Video |
| Oct 15, 2010 | OPEN DATE | | | | |
| Oct 22, 2010 | Crittenden County | HOME | 7:30 | (W) 38-19 | Watch Video |
| Oct 29, 2010 | Caldwell County | HOME | 7:30 | (W) 49-0 | Watch Video |
| Nov 4, 2010 | Caverna | HOME (1st ROUND PLAYOFFS) | 7:30 | (W) 63-14 | Watch Video |
| Nov 12, 2010 | Ballard Memorial | HOME (2nd ROUND PLAYOFFS) | 7:30 | (W) 56-7 | Watch Video |
| Nov 19, 2010 | Louisville Holy Cross | AWAY (3rd ROUND PLAYOFFS) | 7:30 (6:30 CST) | (W) 59-14 | Watch Video |
| Nov 26, 2010 | Beechwood | AWAY (4th ROUND PLAYOFFS) | 6:30 CST | (W) 38-14 | Watch Video |
| Dec 3, 2010 | Hazard | WKU - State Championship | 11:00 A.M. CST | (W) 47-6 | Watch Video |